abstract：:Delta-6 desaturase (D6D) catalyzes the first step in the synthesis of highly unsaturated fatty acids (HUFA) such as arachidonic (AA), docosapentaenoic (DPAn-6), and docosahexaenoic (DHA) acids, as well as the last desaturation of DPAn-6 and DHA. We created D6D-null mice (-/-), which enabled us to study HUFA deficiency...

journal_title：Journal of lipid research

authors： Stroud CK,Nara TY,Roqueta-Rivera M,Radlowski EC,Lawrence P,Zhang Y,Cho BH,Segre M,Hess RA,Brenna JT,Haschek WM,Nakamura MT

更新日期：2009-09-01 00:00:00

abstract：:Clock genes respond to external stimuli and exhibit circadian rhythms. This study investigated the expression of clock genes in the small intestine and their contribution in the regulation of nutrient absorption by enterocytes. We examined expression of clock genes and macronutrient transport proteins in the small int...

journal_title：Journal of lipid research

authors： Pan X,Hussain MM

更新日期：2009-09-01 00:00:00

abstract：:Sixteen hyperlipidemic men were enrolled in a randomized, placebo-controlled, double-blind, cross-over study to evaluate the effect of ezetimibe 10 mg and simvastatin 40 mg, coadministered and alone, on the in vivo kinetics of apolipoprotein (apo) B-48 and B-100 in humans. Subjects underwent a primed-constant infusion...

journal_title：Journal of lipid research

authors： Tremblay AJ,Lamarche B,Hogue JC,Couture P

更新日期：2009-07-01 00:00:00

abstract：:Apolipoprotein B (apoB) is a nonexchangeable apolipoprotein. During lipoprotein assembly, it recruits phospholipids and triacylglycerols (TAG) into TAG-rich lipoprotein particles. It remains bound to secreted lipoproteins during lipid metabolism in plasma. The beta1 region (residues 827-1880) of apoB has a high amphip...

journal_title：Journal of lipid research

authors： Wang L,Martin DD,Genter E,Wang J,McLeod RS,Small DM

更新日期：2009-07-01 00:00:00

abstract：:Human apolipoprotein C-I (apoC-I) is an exchangeable apolipoprotein that binds to lipoprotein particles in vivo. In this study, we employed a LC-MS/MS assay to demonstrate that residues 38-51 of apoC-I are significantly protected from proteolysis in the presence of 1,2-dimyristoyl-3-sn-glycero-phosphocholine (DMPC). T...

journal_title：Journal of lipid research

authors： James PF,Dogovski C,Dobson RC,Bailey MF,Goldie KN,Karas JA,Scanlon DB,O'Hair RA,Perugini MA

更新日期：2009-07-01 00:00:00

abstract：:Sphingolipids are ubiquitous components of eukaryotic cells that regulate various cellular functions. In many cell types, a fraction of sphingolipids contain 2-hydroxy fatty acids, produced by fatty acid 2-hydroxylase (FA2H), as the N-acyl chain of ceramide [hydroxyl fatty acid (hFA)-sphingolipids]. FA2H is highly exp...

journal_title：Journal of lipid research

authors： Alderson NL,Hama H

更新日期：2009-06-01 00:00:00

abstract：:The accumulation of phosphatidylcholine hydroperoxide (PCOOH), a primary oxidation product of phosphatidylcholine (PC), in blood plasma and tissues has been observed in various pathological conditions, including atherosclerosis. However, the biological roles of PCOOH in these conditions remain unknown. To estimate the...

journal_title：Journal of lipid research

authors： Asai A,Okajima F,Nakagawa K,Ibusuki D,Tanimura K,Nakajima Y,Nagao M,Sudo M,Harada T,Miyazawa T,Oikawa S

更新日期：2009-05-01 00:00:00

abstract：:Apolipoprotein AV (apoAV) overexpression causes a decrease in plasma triglyceride (TG) levels, while deficiency of apoAV causes hypertriglyceridemia in both men and mice. However, contrary to what would be expected, plasma apoAV and TG levels in humans are positively correlated. To address this apparent paradox, we de...

journal_title：Journal of lipid research

authors： Vaessen SF,Dallinga-Thie GM,Ross CJ,Splint LJ,Castellani LW,Rensen PC,Hayden MR,Schaap FG,Kuivenhoven JA

更新日期：2009-05-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States and, indeed, worldwide. It has become a global public health issue. In the United States, the prevalence in the general population is estimated at approximately 20%, while that in the morbidly obese population at approximate...

journal_title：Journal of lipid research

authors： Erickson SK

更新日期：2009-04-01 00:00:00

abstract：:We measured plasma markers of cholesterol synthesis (lathosterol) and absorption (campesterol, sitosterol, and cholestanol) in order to compare the effects of maximal doses of rosuvastatin with atorvastatin and investigate the basis for the significant individual variation in lipid lowering response to statin therapy....

journal_title：Journal of lipid research

authors： van Himbergen TM,Matthan NR,Resteghini NA,Otokozawa S,Ai M,Stein EA,Jones PH,Schaefer EJ

更新日期：2009-04-01 00:00:00

abstract：:This review presents an overview of mammalian phospholipid synthesis and the cellular locations of the biochemical activities that produce membrane lipid molecular species. The generalized endoplasmic reticulum compartment is a central site for membrane lipid biogenesis, and examples of the emerging relationships betw...

journal_title：Journal of lipid research

authors： Fagone P,Jackowski S

更新日期：2009-04-01 00:00:00

abstract：:H-Rev107 is a protein that was previously cloned as a negative regulator of proto-oncogene Ras and classified as a class II tumor suppressor. Its structural similarity to lecithin retinol acyltransferase and Ca2+-independent phosphatidylethanolamine (PE) N-acyltransferase led us to analyze H-Rev107 as an enzyme involv...

journal_title：Journal of lipid research

authors： Uyama T,Morishita J,Jin XH,Okamoto Y,Tsuboi K,Ueda N

更新日期：2009-04-01 00:00:00

abstract：:The Singer-Nicholson model of membranes postulated a uniform lipid bilayer randomly studded with floating proteins. However, it became clear almost immediately that membranes were not uniform and that clusters of lipids in a more ordered state existed within the generally disorder lipid milieu of the membrane. These c...

journal_title：Journal of lipid research

authors： Pike LJ

更新日期：2009-04-01 00:00:00

abstract：:The mammalian FA-binding proteins (FABPs) bind long-chain FA with high affinity. The large number of FABP types is suggestive of distinct functions in specific tissues. Multiple experimental approaches have shown that individual FABPs possess both unique and overlapping functions, some of which are based on specific e...

journal_title：Journal of lipid research

authors： Storch J,McDermott L

更新日期：2009-04-01 00:00:00

abstract：:Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s. Vertebrate LP receptors regulate embryogenesis, vascular development, neurogenesis, uterine development, oocyte survival, immune ce...

journal_title：Journal of lipid research

authors： Skoura A,Hla T

更新日期：2009-04-01 00:00:00

abstract：:Common forms of metabolic and cardiovascular diseases involve the interplay of numerous genes as well as important environmental factors. Traditional biochemical and genetic approaches generally attempt to dissect these diseases one gene at a time, for example, by analysis of Mendelian forms or genetically engineered ...

journal_title：Journal of lipid research

authors： Wu S,Lusis AJ,Drake TA

更新日期：2009-04-01 00:00:00

abstract：:The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammato...

journal_title：Journal of lipid research

authors： Reue K,Dwyer JR

更新日期：2009-04-01 00:00:00

abstract：:Lipid peroxidation is a common event in health and is greatly accelerated in pro-inflammatory settings such as hypercholesterolemia. Consequently, oxidation-specific epitopes are generated, which are pro-inflammatory and immunogenic, leading to both adaptive and innate responses. Because innate immune mechanisms use c...

journal_title：Journal of lipid research

authors： Hartvigsen K,Chou MY,Hansen LF,Shaw PX,Tsimikas S,Binder CJ,Witztum JL

更新日期：2009-04-01 00:00:00

abstract：:Lipid transfer inhibitor protein (LTIP) is a regulator of cholesteryl ester transfer protein (CETP) function. Factors affecting plasma LTIP levels are poorly understood. In humans, plasma LTIP is elevated in hypercholesterolemia. To define possible mechanisms by which hyperlipidemia modifies LTIP, we investigated the ...

journal_title：Journal of lipid research

authors： Izem L,Morton RE

更新日期：2009-04-01 00:00:00

abstract：:Elongation of very long chain fatty acids (ELOVL)5 is one of seven mammalian fatty acid condensing enzymes involved in microsomal fatty acid elongation. To determine the in vivo substrates and function of ELOVL5, we generated Elovl5(-/-) mice. Studies using liver microsomal protein from wild-type and knockout mice dem...

journal_title：Journal of lipid research

authors： Moon YA,Hammer RE,Horton JD

更新日期：2009-03-01 00:00:00

abstract：:ABCA1 exports cholesterol and phospholipids from cells by a multistep pathway that involves forming cell surface lipid domains, solubilizing these lipids by apolipoproteins, binding of apolipoproteins to ABCA1, and activating signaling processes. Here we used a mutational analysis approach to evaluate the relationship...

journal_title：Journal of lipid research

authors： Vaughan AM,Tang C,Oram JF

更新日期：2009-02-01 00:00:00

abstract：:Nuclear hormone receptors liver X receptor (LXRalpha and LXRbeta) ligands are attractive approaches for the treatment of dyslipidemia and atherosclerosis. To further elucidate the function of LXRalpha in liver lipid metabolism in a disease-relevant animal model, the KKAy mouse, we used adenoviral vectors to selectivel...

journal_title：Journal of lipid research

authors： Rippmann JF,Schoelch C,Nolte T,Pavliska H,van Marle A,van Es H,Prestle J

更新日期：2009-01-01 00:00:00

abstract：:As 5-lipoxygenase (5-LO) is an emerging target in obesity and insulin resistance, we have investigated whether this arachidonate pathway is also implicated in the progression of obesity-related fatty liver disease. Our results show that 5-LO activity and 5-LO-derived product levels are significantly elevated in the li...

journal_title：Journal of lipid research

authors： López-Parra M,Titos E,Horrillo R,Ferré N,González-Périz A,Martínez-Clemente M,Planagumà A,Masferrer J,Arroyo V,Clària J

更新日期：2008-12-01 00:00:00

abstract：:Cholesterol 7alpha-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance. We evaluated the effect of a common -203A>C polymorphism in the CYP7A1 pro...

journal_title：Journal of lipid research

authors： Lenícek M,Komárek V,Zimolová M,Kovár J,Jirsa M,Lukás M,Vítek L

更新日期：2008-12-01 00:00:00

abstract：:Plasma phospholipid transfer protein (PLTP) interacts with HDL particles and facilitates the transfer of phospholipids from triglyceride (TG)-rich lipoproteins to HDL. Overexpressing human PLTP in mice increases the susceptibility to atherosclerosis. In human plasma, high-active and low-active forms of PLTP exist. To ...

journal_title：Journal of lipid research

authors： Samyn H,Moerland M,van Gent T,van Haperen R,Metso J,Grosveld F,Jauhiainen M,van Tol A,de Crom R

更新日期：2008-12-01 00:00:00

abstract：:Matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) has been applied primarily to the analysis of glycosphingolipids separated from other complex mixtures by TLC, but it is difficult to obtain quantitative profiling of each glycosphingolipid among the different spots on TLC by MALDI-MS. Thus, the ...

journal_title：Journal of lipid research

authors： Ikeda K,Shimizu T,Taguchi R

更新日期：2008-12-01 00:00:00

abstract：:4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar excess of apoA-I. Physiologic concentrations ( approximately 35 microM) of human apoA-I did not inhibit the production of LDL-induced monocyte chemotactic activity...

journal_title：Journal of lipid research

authors： Van Lenten BJ,Wagner AC,Jung CL,Ruchala P,Waring AJ,Lehrer RI,Watson AD,Hama S,Navab M,Anantharamaiah GM,Fogelman AM

更新日期：2008-11-01 00:00:00

abstract：:Previous studies from our laboratory indicated that pre-germinated brown rice (PR) contained certain unknown bioactive lipids that activated two enzymes related to diabetes: Na+/K+ATPase and homocysteine-thiolactonase. In this paper, we report on the isolation and structural characterization of the activator lipids fr...

journal_title：Journal of lipid research

authors： Usuki S,Ariga T,Dasgupta S,Kasama T,Morikawa K,Nonaka S,Okuhara Y,Kise M,Yu RK

更新日期：2008-10-01 00:00:00

abstract：:Cholelithiasis is a multifactorial process, and several mechanisms have been postulated. A decreased expression of the ileal apical sodium-dependent bile acid transporter (ASBT) and of the cytosolic ileal lipid binding protein (ILBP) was recently described in female non-obese patients. The role of the recently identif...

journal_title：Journal of lipid research

authors： Renner O,Harsch S,Strohmeyer A,Schimmel S,Stange EF

更新日期：2008-09-01 00:00:00

abstract：:Inflammatory lipid mediators derived from arachidonic acid (AA) and docosahexaenoic acid (DHA) modify the pathophysiology of brain ischemia. The goal of this work was to investigate the formation of eicosanoids and docosanoids generated from AA and DHA, respectively, during no-flow cerebral ischemia. Rats were subject...

journal_title：Journal of lipid research

authors： Farias SE,Basselin M,Chang L,Heidenreich KA,Rapoport SI,Murphy RC

更新日期：2008-09-01 00:00:00

abstract：:Niemann-Pick C1-like 1 (NPC1L1) is a recently identified protein that mediates intestinal cholesterol absorption and regulates biliary cholesterol excretion. The itineraries and kinetics of NPC1L1 trafficking remain uncertain. In this study, we have visualized movement of NPC1L1-enhanced green fluorescent protein (NPC...

journal_title：Journal of lipid research

authors： Petersen NH,Faergeman NJ,Yu L,Wüstner D

更新日期：2008-09-01 00:00:00

abstract：:The extent to which the heart can convert alpha-linolenic acid (alpha-LNA, 18:3n-3) to longer chain n-3 PUFAs is not known. Conversion rates can be measured in vivo using radiolabeled alpha-LNA and a kinetic fatty acid model. [1-(14)C]alpha-LNA was infused intravenously for 5 min in unanesthetized rats that had been f...

journal_title：Journal of lipid research

authors： Igarashi M,Ma K,Chang L,Bell JM,Rapoport SI

更新日期：2008-08-01 00:00:00

abstract：:The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve lesions. Serum samples were collected from 82 patients with severe AS a...

journal_title：Journal of lipid research

authors： Helske S,Miettinen T,Gylling H,Mäyränpää M,Lommi J,Turto H,Werkkala K,Kupari M,Kovanen PT

更新日期：2008-07-01 00:00:00

abstract：:The objective of this study was to establish a new lipoprotein lipase (LPL) and hepatic lipase (HL) activity assay method. Seventy normal volunteers were recruited. Lipase activities were assayed by measuring the increase in absorbance at 546 nm due to the quinoneine dye. Reaction mixture-1 (R-1) contained dioleoylgly...

journal_title：Journal of lipid research

authors： Imamura S,Kobayashi J,Nakajima K,Sakasegawa S,Nohara A,Noguchi T,Kawashiri MA,Inazu A,Deeb SS,Mabuchi H,Brunzell JD

更新日期：2008-07-01 00:00:00

abstract：:Apolipoprotein E2 (apoE2)-associated hyperlipidemia is characterized by a disturbed clearance of apoE2-enriched VLDL remnants. Because excess apoE2 inhibits LPL-mediated triglyceride (TG) hydrolysis in vitro, we investigated whether direct or indirect stimulation of LPL activity in vivo reduces the apoE2-associated hy...

journal_title：Journal of lipid research

authors： Gerritsen G,van der Hoogt CC,Schaap FG,Voshol PJ,Kypreos KE,Maeda N,Groen AK,Havekes LM,Rensen PC,van Dijk KW

更新日期：2008-05-01 00:00:00

abstract：:LPL is an enzyme involved in the breakdown and uptake of lipoprotein triglycerides. In the present study, we examined how the transgenic (Tg) overexpression of human LPL in mouse skeletal muscle affected tolerance to cold temperatures, cold-induced thermogenesis, and fuel utilization during this response. Tg mice and ...

journal_title：Journal of lipid research

authors： Jensen DR,Knaub LA,Konhilas JP,Leinwand LA,MacLean PS,Eckel RH

更新日期：2008-04-01 00:00:00

abstract：:Previous studies have reported both positive and negative effects of culture of islets at high glucose concentrations on regulated insulin secretion. Here, we have reexamined this question in mouse islets and determined the role of changes in lipid synthesis in the effects of glucose. Glucose-stimulated insulin secret...

journal_title：Journal of lipid research

authors： Diraison F,Ravier MA,Richards SK,Smith RM,Shimano H,Rutter GA

更新日期：2008-04-01 00:00:00

abstract：:Ceramide-1-phosphate (C1P) is a novel bioactive sphingolipid formed by the phosphorylation of ceramide catalyzed by ceramide kinase (CERK). In this study, we evaluated the mechanism by which increased C1P during phagocytosis enhances phagocytosis and phagolysosome formation in COS-1 cells expressing hCERK. Stable tran...

journal_title：Journal of lipid research

authors： Hinkovska-Galcheva V,Clark A,VanWay S,Huang JB,Hiraoka M,Abe A,Borofsky M,Kunkel RG,Shanley T,Shayman JA,Lanni F,Petty HR,Boxer LA

更新日期：2008-03-01 00:00:00

abstract：:Human striated muscle samples, from male control and Duchenne muscular dystrophy-affected children, were subjected to cluster-time-of-flight secondary ion mass spectrometry (cluster-ToF-SIMS) imaging using a 25 keV Bi(3)(+) liquid metal ion gun under static SIMS conditions. Spectra and ion density maps, or secondary i...

journal_title：Journal of lipid research

authors： Tahallah N,Brunelle A,De La Porte S,Laprévote O

更新日期：2008-02-01 00:00:00

abstract：:Sebaceous glands are intriguing glands that are found throughout the human body except on the palms of the hands and soles of the feet. The true function of these glands has yet to be determined, but there are several theories, including antioxidant effects, antibacterial effects, and transport of pheromones. Sebaceou...

journal_title：Journal of lipid research

authors： Smith KR,Thiboutot DM

更新日期：2008-02-01 00:00:00